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Attachment B
ACC Prioritization Screening Approach
L Introduction
This document provides background on ACC's approach to chemical prioritization
screening. The approach is based on the following general principles:
The purpose of this approach is to identify substances as priority to receive more detailed
evaluation and assessment which, when conducted, could possibly lead to risk management
measures .
Apply a science- and risk-based approach, considering both the degree of hazard and extent of
exposure potential in setting priorities.
Include criteria applicable to the range of chemicals being screened. Apply this principle
through a two-step process rather than just those information elements available only for
subsets of chemicals.
Leverage available data and existing hazard classification frameworks already in use across industry
and agreed by regulators.
.
Incorporate relevant science advances where there is broad acceptance in the scientific
community, e.g. improvements in how persistence and bioaccumulation considerations are
addressed.
Allow for the incorporation of significant new information to ensure prioritization decisions
remain current.
.
Adopt a simple, transparent screening method.
Include opportunity for public review and comment to ensure the best available data and
information is used in prioritization decisions.
Allow professional judgment to be applied where appropriate, e.g. in hazard classification
and second-tier ranking.
IL. Applying Initial Screening Step in ACC's Prioritization Approach
The first step in applying ACC's prioritization approach is to apply criteria on human
health and environmental toxicity potential to chemical substances.
A. Hazard Potential
The U.N. Globally Harmonized System of Classification and Labeling (GHS) was
developed and internationally agreed to by many governments to provide criteria and a consistent
approach for hazard classification of chemicals. It can also provide a recognized and generally
accepted method for sorting chemicals in a prioritization process. The GHS framework has been
used by international bodies, such as the OECD and WHO, and was endorsed by EPA's National
Pollution Prevention and Toxics Advisory Committee (NPPTAC) to support prioritization.
The GHS system applies to both human health and ecological endpoints. It includes
criteria for both human and ecological health. For human health, criteria are available for both
acute and chronic classifications, as well as CMR categorization. For ecological
August 29, 2011
Source: https://www.industrydocuments.ucsf.edu/docs/jzbn0226

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