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PHILIP MORRIS. U. S.A.
INTER - OFFICE CORRESPONDENCE
Richmond, Virginia
To:
.Dr. Richard Carchman
Date: May 9, 1990
From:
.Maria Shulleeta
Subject:
.Prospective Alternate Preservatives List for Phase I Screening
After examining pertinant literature and discussing with knowledgeable PM personnel the
company's continuing need for an alternate preservative for the RL process , a number of
compounds have been identified for screening in Phase I preservative assays. Some of these
compounds are known tobacco constituents whose structures are similiar to other compounds
which have demonstrated significant antimicrobial activity in our assays. Other compounds on
the proposed list are essential oils or essential oil components which are known to have
antimicrobial activity in other test systems. The prospective test compounds are listed below
with their CAS numbers (where known). Please comment on the acceptability of the use of
these compounds in our processes. It is important to consider that any compound that is would
have to be effective (complete inhibition of bacterial growth for 24 hours) at low dose (<300
ug/ml) in Phase I screening before subsequent testing in the Phase III fermentor-scale assay or
subjective screening would be suggested. In evaluating the listed compounds, please indicate a
priority for screening by rating the compounds for acceptability (e.g., very acceptable
Mono
compounds would be rated "1" and consequently tested first):
CA
18
RTECS:
Compound
CAS number
HSAB
ATECS
MDNO Caryophyllene
87-44-5
V
Sclareol
515-03-7 7
Sclareolide
564-20-5
HSOB
RTECS
Fumaric Acid
X
110-82-2 110-17-8
Taxnets
2-phenylethyl valerate
7460-74-4 /
Send to OMaria
HSDP
Moro Phenyl acetic acid
103-82-2. J
Abietic acid
514-10-3 /
# 1902
KTECS
Xanthophyll
127- 440 -2
RTECS
MciJo Basil oil
8015-73-4
RTECS MONO: Bay oil
8006- 78-8
ASDe
PTECS
MONO Cumin oil."
8014-13-9 7
RTECS
MONO Lemongrass oil
8007-02-1
ITECS
1. 1010
Caraway oil
8000-42-8 /
H.DB
RTECE
MONO
Orange oil
208- 57-9
Mero Oakmoss oil
9000-50-4
VTECS MONO Phenylacetaldehyde
122-78:1
2022156519
Source: https://www.industrydocuments.ucsf.edu/docs/ljxj0037

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