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PROGRESS REPORT 24
Trimegestone
CLIENT
AVENTIS
WYETH-AYERST
CONTACTS
Aventis:
Peter Miller
(peter.miller@aventis.com)
00 331 4991 5848
Louise Silvestre
(00 331 4991 4996)
Wyeth:
Dave Downey
(downey @labs. wyeth.com)
Russell Neubauer (neubaur(@war.wyeth.com)
Current Projects
(001 610341 2092)
Rick Winneker
(001 610 989 4832)
DATE
16" March 2001
PAPERS
PROJECT
CLASSIFICATION
TARGET
STATUS / ACTION
PUBLICATION
DATE/JOURNAL
TRIMEGESTONE PRECLINICAL
P2(1)
Pharmacology
Published
The pharmacological profile of a
Gynecological Endocrinology 1999; 13:316-26
novel norpregnane progestin
(trimegestone)
D. Philibert et al.
P2(2) FAST TRACK
Bone
Q2001
Effects of 17p-estradiol and
Endometrium
Sign-off from Aventis and Wyeth agreed. Submitted to
rimegestone alone, and in
Climacteric
Climacteric 26.02.01
combination, on the bone and uterus
of ovariectomized rats
L. Lepescheux et al.
P2(3 )
Pharmacokinetics
Q 2001
A pharmacokinetic investigation of
Awaiting comments from Aventis (Claude Bonnat)
trimegestone in the rat and
Kenobiotica or Drug
Reminder sent 18.9.00
Cynomolgus monkey following
Metab Disposition
intravenous, oral or percutaneous
administration
P2(8) FAST TRACK
Bone
Published
Gynecological Endocrinology, 2001; 15:48-55
Effect of trimegestone alone or in
combination with estradiol on bone
mass and bone turnover in an adult
model of osteopenia
Y. Bouali et al.
TRIMEGESTONE (2 mg) PHASE 2
P2(4)
Pharmacokinetics
1Q2001
Paper under revision
Trimegestone: pharmacokinetics and
bioavailability in human volunteers
following a single oral
administration
P2(7 )
Metabolism
Q2001
Animal and human metabolism in
Data not yet supplied to Parthenon. On hold
vivo and in vitro
Peter Miller/Bernard Lenfant to provide Dossier
Confidential Pursuant to Confidentiality
WINNR201-004704
Order
Source: https://www.industrydocuments.ucsf.edu/docs/gncw0217

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