Output Explorer

29
Table 3. Possible Reasons for the Discrepancy Between the Findings of Observational Studies
and Those of Randomized Trials in the Prevention of CHD in Postmenopausal Women
HERS/ERA
Observational
CHD status
Secondary prevention of
Primary prevention of CHD
established CHD
Age of participants
Mean 265 years
Mean = ~55-60 years
Treatment
CEE plus progestins
Usually unopposed estrogens
Study design/Selection bias
Random assignment to HRT
Self-selection bias--HRT
or placebo
users younger, healthier
Event-related dropout
Excess early CV events
Possible loss of those with
early CV events
Observation time
Shorter
Longer
Time since menopause
Mean = 23.1 years
Mean <5 years
Method of analysis
Intent-to-treat
On-treatment
Confidential Pursuant to Confidentiality
SOLOJO10-002105
Order
Source: https://www.industrydocuments.ucsf.edu/docs/plvw0217

Answer the question using only the OCR text from a single document page. Return only the answer, with no explanation. Preserve the answer wording from the OCR text when possible.